McGuire, who had just 41 yards in the first half, now has 13 games with 100 or more yards rushing. Jennings was 15-of-21 passing and Ja'Marcus Bradley grabbed six for 97 yards.
Louisiana-Lafayette (1-1) was up 14-12 at the break. The Cowboys took their only lead when Trent Manuel nailed a 28-yard field goal with 9:31 left in the third quarter. The Ragin' Cajuns responded quickly, retaking the lead for good on Raymond Calais' rushing score from the seven with 7:18 left.
McNeese State (1-1) closed to within eight when Dylan Long plunged in from the three with 12 seconds left. The ensuing onside kick failed.
James Tabary threw for 237 yards for McNeese State.
Looking ahead to 'Jalen's next journey' at Oklahoma
By transferring to Oklahoma, Jalen Hurts is looking to revitalize his own career and get the Sooners back into championship contention.
Kendall's transfer to WVU hitting a snag
Jake Trotter reports the latest on Austin Kendall's efforts to transfer away from Oklahoma.
FIU's Butch Davis: Miami game at old Orange Bowl site will be 'magic'
FIU and the Marlins unveiled plans for the Nov. 23 game between the Golden Panthers and Hurricanes at Marlins Park -- built on the site where the Orange Bowl, Miami's former home field, stood before it was demolished more than a decade ago.
Foxworth, Spears get heated about Murray's NFL potential
Domonique Foxworth and Marcus Spears get fired up debating if Kyler Murray should play baseball or football.
Tosh Lupoi leaving Alabama; Butch Jones back for 2019 season
Alabama defensive coordinator Tosh Lupoi became the latest coach to leave Nick Saban's staff, with sources confirming to ESPN that he is taking a job with the Cleveland Browns.
Oklahoma QB Austin Kendall will be able to play immediately for West Virginia
Oklahoma, after initially blocking quarterback Austin Kendall from transferring to West Virginia, will allow the graduate student to play for the Mountaineers next season, sources say.