Central Connecticut State (5-3, 3-0 Northeast Conference) won its fifth straight while Bryant (2-5, 0-2) has lost three consecutive games.
Rush ran for a 3-yard score and had a 70-yard touchdown catch in the first quarter. Jean-Guillaume finished with 123 yards rushing, including a 76-yard touchdown run late in the third quarter.
Price Wilson was 26-of-42 passing for 381 yards to lead Bryant. It was Wilson's sixth game this season with over 300 yards passing. Wilson connected with Tom Kennedy on a 51-yard touchdown pass, and ran for a 1-yard score in the third quarter. Kennedy had five catches for 161 yards.
CCSU recovered two fourth-quarter Bryant fumbles, the first led to Carlton Nash's 1-yard touchdown run that capped the scoring with 6:34 left.
More AP college football: http://collegefootball.ap.org and http://www.twitter.com/AP-Top25
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