Nevada had five 40-plus-yard touchdowns. Daniel Brown returned an interception 42 yards, Mannix scored from 47 and 58 yards out, Jaxson Kincaide added a 73-yard grab and Romeo Doubs went 80 yards on a punt return.
It was the fifth-highest scoring output in Nevada's history and the most in its FBS era, which began in 1992.
Gangi was 16-of-26 passing for 342 yards and three TDs, and Mannix caught four passes for 132 yards. Doubs gave Nevada its first punt return touchdown since 2011.
Nevada scored 23 unanswered points for a 23-9 lead and it was 30-19 at halftime before the Wolf Pack took control with 42 straight points.
Touchdowns on six straight drives put Nevada ahead 58-19.
Cole McDonald threw five touchdown passes to four different receivers and Hawaii limited Duquesne to just 166 total yards as the Rainbow Warriors beat the Dukes 42-21 on Saturday night.
John Baron made three field goals, including the winning 38-yarder in overtime, to help San Diego State beat Eastern Michigan 23-20 on Saturday night.
Utah State running back Gerold Bright takes the hand off then shows off the speed scoring a 70-yard TD.
John Baron II makes a 39-yard field goal right down the middle to secure the 23-20 win for San Diego State.
Jake Browning threw a pair of touchdown passes in the first quarter, added a third TD toss early in the fourth quarter, and No. 10 Washington outlasted Arizona State 27-20 on Saturday night.
The Sooners were tested at home, but the normally-prolific offense got a lift from the defense to overcome a missed FG at the end of regulation.