Nevada had five 40-plus-yard touchdowns. Daniel Brown returned an interception 42 yards, Mannix scored from 47 and 58 yards out, Jaxson Kincaide added a 73-yard grab and Romeo Doubs went 80 yards on a punt return.
It was the fifth-highest scoring output in Nevada's history and the most in its FBS era, which began in 1992.
Gangi was 16-of-26 passing for 342 yards and three TDs, and Mannix caught four passes for 132 yards. Doubs gave Nevada its first punt return touchdown since 2011.
Nevada scored 23 unanswered points for a 23-9 lead and it was 30-19 at halftime before the Wolf Pack took control with 42 straight points.
Touchdowns on six straight drives put Nevada ahead 58-19.
No. 25 Iowa State, Kansas State still have plenty to prove
Two teams with plenty of goals remaining square off as No. 25 Iowa State hosts Kansas State Saturday evening.
No. 24 Panthers not letting up at Miami
The roles have essentially reversed since Pittsburgh and Miami closed out the 2017 season a year ago in Pittsburgh.
No. 12 Syracuse, Boston College ready to renew rivalry
Two old friends coming off very tough weekends get together for their rivalry game in Chestnut Hill Saturday.
No. 19 Northwestern closes out regular-season vs. Illinois
Northwestern has just a small hurdle to clear in order to maintain momentum heading into the Big Ten title game.
No. 17 Utah , BYU expect competitive matchup
Pac-12 South champion Utah will turn back the clock for a rare late-season rivalry battle with BYU.
Top-ranked Alabama ready for anyhing in Iron Bowl vs. Auburni
Every year you hear the same thing about the Alabama-Auburn rivalry, on how to throw out the records and statistics because anything can happen.