Monaco head coach Leonardo Jardim has warned his underperforming players some of them will need to look for new employment in January.
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Ten-man Porto advanced out of Group G with a 5-2 defeat of a disappointing Monaco side, who also went down a man at the Estadio do Dragao.
Radamel Falcao scored his first Ligue 1 goal in more than a month to end defending champions Monaco's bad patch with a 1-0 win over Angers.
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Monaco returned to winning ways after beating Caen 2-0 at Stade Louis II.