They fell behind just before half-time but two goals in as many minutes after the break saw Jose Mourinho's men secure a UCL last-16 place.
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Manchester United secured top spot in Group A of the Champions League, but had to come from behind to beat CSKA Moscow 2-1.
Jose Mourinho missed out on Brazilian defender Mario Fernandes during his time at Real. Now playing for Russia, Fernandes faces Man United with CSKA.
CSKA Moscow coach Viktor Goncharenko believes his side's bad luck will be Manchester City's gain as he prepares to face Paul Pogba at Old Trafford.
Paul Pogba will start against CSKA Moscow despite his red card against Arsenal, while David De Gea and Zlatan Ibrahimovic will be rested.
Igor Akinfeev kept his first Champions League clean sheet in more than 11 years as CSKA Moscow beat Benfica 2-0 on Wednesday.
CSKA Moscow moved closer to a spot in the Champions League round of 16 with a 2-0 win over Benfica on Wednesday.
Basel missed a chance to advance by letting a lead slip and losing 2-1 at home to CSKA Moscow.
Basel continued a strong start to their Champions League campaign with a 2-0 win at CSKA Moscow on Wednesday.
Romelu Lukaku scored twice and Anthony Martial also shone as Manchester United cruised to a 4-1 win away to CSKA Moscow to stay perfect in Group A.
Ashley Young will captain Manchester United against CSKA Moscow in the Champions League on Wednesday, while Victor Lindelof has received a rare start.
Aleksandr Golovin has made the unlikely jump from being a skinny Siberian midfielder to an international football star. And he's just getting started.
CSKA Moscow are expecting a tough tie against what coach Viktor Goncharenko says is the best Manchester United side since Sir Alex Ferguson retired.
The head of Russian football's security committee has warned Manchester United and Liverpool supporters against causing trouble this week.
CSKA Moscow forward Timur Zhamaletdinov made a memorable Champions League debut on Tuesday by scoring the winner in a 2-1 comeback victory at Benfica.
Liverpool and Manchester United will play in Moscow on successive nights after English football's greatest rivals were paired to face Spartak and CSKA
The draw was kind to Manchester United, but a trip to Russia and a rematch of the 1968 European Cup final await improved United, writes Nick Ames.
Liverpool earned a first-leg away win at Hoffenheim while CSKA needed a fortunate own goal to edge Young Boys.
Akinfeev had conceded in his last 40 matches in the competition.
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