Martin and Baldwin combined to shoot 12 of 22 from the field and Butler (6-2) shot 49.1 percent (26 of 53). Butler led 8-0 and never trailed. Javon Bess made a pair of free throws 4 1/2 minutes into the game for Saint Louis' (3-4) first points.
Butler closed the half on a 6-0 run for a 42-13 led and were never challenged the rest of the way. The Billikens now have lost four straight by an average margin of 18.2 points per game.
Javon Bess scored 22 points and had 10 rebounds for Saint Louis.
Guard Alex O'Connell will miss the remaining two games of the Duke Blue Devils' Canada tour with a broken bone in his face.
Duke freshman R.J. Barrett talks with the school's creative director to discuss his social media habits and how he should brand himself.
In his first game action with Duke, Zion Williamson drops 29 points and 13 rebounds in an exhibition game against Ryerson.