Hamilton went 5 of 9 from 3-point range and 7 of 11 overall and made all six of his free throws. Blackston was 10 of 11 from the field. Iwin Ellis and J.D. Wallace had 10 points apiece for the Panthers (3-11) and Dennis Jones had eight points and 10 assists.
Prairie View A&M shot 70 percent (21 of 30) in the first half with eight 3-pointers. Hamilton had 22 points and Blackston 18 as the Panthers opened a 59-32 lead over the Bulldogs, who shot 52 percent.
The lead reached 40 less than five minutes into the second half. All 11 players scored for the Panthers.
Isaiah Lopez had 12 points for Jarvis Christian.
Williams: Duke intimidates teams during warmups
Jay Williams has seen Duke beat teams in warmups because some opponents will be in awe of Zion Williamson, RJ Barrett and Cam Reddish.
Williams throws down one-handed hammer
Cincinnati's Keith Williams finishes a fast break with a vicious jam.
Brooks throws it down on a Wichita State defender
Nysier Brooks catches a lob and throws down a dunk over a Wichita State defender to extend Cincinnati's lead.