England prop Joe Marler looks set to miss the start of the Six Nations after he was ruled out of action for up to five weeks with a broken leg.
Marler pulled up in the warm-up ahead of Harlequins' win over Sale last weekend but was initially told he had not suffered a fracture.
However, a subsequent MRI scan has revealed the full extent of the injury, with Harlequins confirming on Wednesday that he will be out for up to between four and five weeks.
That timeframe would appear to rule Marler out until after England's opening Six Nations clash with France on Feb. 4.
The news is a further blow for England boss Eddie Jones who was already without Saracens loosehead Mako Vunipola due to a knee injury.
"Harlequins can confirm today that Joe Marler has suffered a fracture to his lower left leg," a statement on the club's website said.
"He will undergo a period of rehabilitation and is expected to be fit to play again in four to five weeks.
"We will provide updates on his progress as and when appropriate."