The Chiefs moved top with a dominant 31-13 victory over their rivals at Sandy Park.
Exeter Chiefs and England winger Nowell tore his hamstring during the November internationals and faces a race to be fit for the Six Nations.
Exeter Chiefs have announced the signing of Scotland international Stuart Hogg on a two-year deal.
Former England and Exeter Chiefs forward Thomas Waldrom has retired from rugby.
Brian O'Driscoll has tipped Exeter Chiefs as favourites to win the Champions Cup title this season, alongside recent winners Leinster and Saracens.
England backrower Sam Simmonds will be out for the next six to nine months after tearing his ACL, casting doubt over his chances of playing at next year's Rugby World Cup.
Saracens and Exeter Chiefs' blistering start to the Premiership season shows they are ahead of the rest of the division, according to Worcester's Alan Solomons.
From best opposition player to best dressing-room DJ, Premiership stars such as Danny Care and Jack Nowell give us the lowdown ahead of the new season.
Leinster and Saracens fans were smiling this weekend as domestic honours were secured, while Castres set up a mouthwatering Top 14 final in Paris next weekend.
It has been a season of highs and lows for Saracens, but they have finished it off in style.
Exeter and Saracens bring down the curtain on another thrilling Aviva Premiership season, and a couple of storied careers, when they meet at Twickenham on Sunday.
Exeter boss Rob Baxter has backed young fly-half Joe Simmonds to relish his key role in Saturday's Aviva Premiership final against Saracens.
James Harrington runs the rule over the Aviva Premiership and PRO14 finals, plus the Top 14 semifinals, to predict which player will shine brightest, who will have an afternoon to forget and a whole lot more.
Billy Vunipola is expected to start Saracens' Aviva Premiership final against Exeter at Twickenham on Saturday despite coming off at halftime in Saracens' semifinal victory over Wasps.
Plenty was sorted out over an enthralling few days but who shone, who had a weekend to forget and what will fans be talking about ahead of a busy period of domestic action?
Rob Baxter praised a "glued together" performance after his Exeter team saw off Newcastle to reach their third successive Aviva Premiership final.
Following eight months of intense competition four teams are left battling for silverware in the Aviva Premiership and PRO14, while Castres, Lyon, Toulon and Toulouse target a place in the Top 14 semifinals.
The 2017-18 Aviva Premiership semifinals take place with Newcastle looking to emulate champions Exeter by beating the Chiefs and punching their ticket to Twickenham.
Ruan Ackermann has been rewarded for a fine first season in England with a place on the shortlist for Premiership Rugby's Discovery of the Year award.
Global insurance brokers Gallagher have been confirmed as new title sponsors of English rugby union's Premiership.
Bath have signed Exeter scrum-half Will Chudley for next season.
Bath and Exeter will have to wait to contest for English club rugby's first silverware of the season after the Anglo-Welsh Cup final was postponed due to adverse weather conditions.
Exeter playmaker Henry Slade has been added to England's lengthening injury list ahead of the Six Nations.
Exeter Chiefs' record points scorer Gareth Steenson has signed a new two-year contract to remain at Sandy Park.
Exeter Director of Rugby Rob Baxter feels his side are wearing sides down in almost every Aviva Premiership game after they scored four second-half tries to beat Leicester 30-6.
- EXET7thTRIES SCORED 1st Leinster : 27 Tries ScoredLEINS1st1827
- EXET8thPOINTS DIFFERENCE 1st Leinster : 116 Points DifferenceLEINS1st20116