United men's players Marcus Rashford, Anthony Martial, Axel Tuanzebe -- on two separate occasions -- Southampton's Alexandre Jankewitz and James' brother Reece, who plays for Chelsea, have all been victims of racist abuse across social media in recent weeks.
James shared a screenshot of abuse she had received on her Instagram story and called on social media platforms to do more.
"Instagram on a really need to do something about it or they will lose so many individuals on their platform -- cause that's the only way they will actually listen," James wrote on her Instagram story.
"Some smart person out there got to be coming up with a platform where you have to prove ID to sign up.
"Instagram doesn't even have a clear 'Racism' option in their reporting system. Could even just remove any emojis with racist meanings.
"Too easy for some kid to press a few emojis in order to try & grab some attention. Too much talk around these days and nothing ever gets done. Usual story."
The Football Association and the Lionesses released a joint statement after James' post in support of her and Tuanzebe.
"Yet another weekend where players are facing discriminatory abuse and having to deal with anonymous keyboard warriors who hide in a world of impunity. Enough is enough," the statement said.
"We implore government to act quickly and bring in the appropriate legislation so this abuse has real life consequences. Social media companies need to step up and take accountability and action to ban abusers from their platforms, gather evidence that can lead to prosecution and support making their platforms free from this type of abhorrent abuse."
"As a white person that will never be able to fully understand what @laurennjjames has had to live through and continues to live through I stand up against racism and stand with you!! @instagram you need to do more it's unacceptable [and] changes need to [be] made," Stoney said in an Instragram story.
James' England teammate Bronze added that it was unacceptable that someone as young as her was facing this abuse: "My kid giving you a lesson.. @Instagram (and the rest) about time you did something!
"And I say kid because this girl is 19!! Her time shouldn't be spent [educating] you in your mistakes."
On Monday, Secretary of State for Digital, Culture, Media and Sport Oliver Dowden said the government would seek to change the law to make social media platforms more accountable.
"Online racist abuse of footballers is absolutely shocking [and] must stop," he said in a statement on Twitter. "In advance of this recent spate of cases, I called a [meeting] to hear first hand accounts of the daily abuse players receive and the awful toll it takes on them.
"We are going to change the law to make social media companies more accountable for what happens on their platforms [and] they can start showing their duty of care to players today by weeding out racist abuse now. Players must not be abused for doing their jobs, enough is enough."