"A couple of years ago, he told me that he will probably end up in America," Nani told ESPN's Taylor Twellman.
"It's not 100% but probably. There is a chance."
The 33-year-old said he had a lot of misconceptions about MLS before he joined.
"It is a great league," Nani added.
"Obviously there are points where we must improve as a league, even in the quality of the players."
The winger said there is still work to be done to get the league up to the standards of its European counterparts but he thinks there is the eagerness to grow it.
"Here you have fantastic clubs, well organised with fantastic conditions, great coaches, great players. You see every season improving," he said.
"I think we all have the conditions in this league. We are in a great country. Everything is around us. It is all about being better, not being afraid to improve."