Wasps hooker Alfie Barbeary has been given his first England call-up after being included in the 33-man squad for Sunday's Autumn Nations Cup final against France.
The 20-year-old made an immediate impact when he scored a try on his Premiership debut from the bench against Worcester Warriors in August and then scored a hat-trick on his first start, against Leicester Tigers in September.
He has won three England Under-20 caps and was part of his country's 2019 World Rugby Under-20 Championship squad.
Joe Marchant and Jacob Umaga have returned to the squad after injury while Jonathan Joseph has withdrawn with a calf problem.
England Rugby also announced that it would allow 2,000 fans to attend the fixture at Twickenham.
The RFU have gifted 20 percent of the seats to local NHS workers with the remaining amount allocated for players families, local rugby clubs and sponsors. The remaining 1,000 tickets will be sold to local residents.
"We're looking forward to seeing fans back in the stadium this weekend. While the numbers are limited, it is an opportunity to operate a socially distanced event as a small step forward in our plans for the return of fans," said RFU CEO Bill Sweeney in a press release.
Joe Cokanasiga, Elliot Daly, Owen Farrell, George Ford, Ollie Lawrence, Max Malins, Joe Marchant, Jonny May, Alex Mitchell, Dan Robson, Henry Slade, Ollie Thorley, Jacob Umaga, Anthony Watson, Ben Youngs.
Alfie Barbeary, Luke Cowan-Dickie, Tom Curry, Ben Earl, Charlie Ewels, Ellis Genge, Jamie George, Jonny Hill, Maro Itoje, Joe Launchbury, Joe Marler, Kyle Sinckler, Will Stuart, Sam Underhill, Billy Vunipola, Mako Vunipola, Harry Williams, Jack Willis.