ROME -- Once is enough when it comes to beating Rafael Nadal on a clay court.
Throughout his career, Nadal has never lost consecutive matches on his favorite surface and the Spaniard extended that perfect record Wednesday by beating John Isner 6-3, 6-1 to reach the third round of the Italian Open.
Perhaps more importantly, Nadal regained some confidence as he works his way back from a rib stress fracture that kept him out for six weeks before the tournament in Madrid.
While he would clearly love to add to his record total of 10 Italian Open titles, Nadal's bigger objective is regaining his top form in time for the French Open, which starts in less than two weeks. Nadal has won 13 of his 21 Grand Slam titles at Roland Garros.
When the match finished, Nadal headed straight to the practice court to hit more balls. He explained that he's a "bit in a rush'' to find his best form "as soon as possible.''
"I need to work as much as I can,'' Nadal said. "The match today was not that demanding physically.''
It was essentially decided during one brief stretch.
Nadal struggled on his serve at 3-3 in the first set, missing a forehand into the net then double-faulting to set up break points for Isner. But the American made unforced errors on both of his break-point opportunities and Nadal eventually held.
In the following game, Nadal broke Isner's serve when the 6-foot-10 American missed a comfortable forehand volley into the net. Nadal then held at love to close out the first set and broke Isner's serve in the opening game of the second.
"I finished better than I started -- without a doubt," Nadal said. "He had some chances on the returns. I was in his hands in that moment. Lucky that he missed those shots."
Nadal improved to 19-0 against Americans on clay, having been forced to a deciding set only twice -- both times by Isner, who pushed Nadal to five sets at the 2011 French Open and three sets at the 2015 Monte Carlo Masters.
Up next, Nadal meets Denis Shapovalov, the Canadian he beat at the same stage last year in a grueling three-set comeback victory in which the Spaniard saved two match points.
"Super lucky," Nadal said, reflecting back to playing Shapovalov last year. "I know how dangerous he is. I need to play better than today."
Three-time Grand Slam champion Stan Wawrinka, playing only his second tournament after more than a year out following two surgeries on his left foot, edged Laslo Djere 7-6 (8), 3-6, 6-4 to set up a meeting with top-ranked Novak Djokovic.
"It's going to be really difficult for me, because I'm not ready to compete -- I think -- at that level,'' Wawrinka said of facing Djokovic. "But it's what I need. I need those challenges. I need to push myself as much as I can to keep improving.''
Wawrinka had loud support from a packed crowd on the picturesque Pietrangeli court, which is lined with statues.
"The reason why after two surgeries, one year out, I'm still playing tennis at 37 years old is to live those moments as much as I can,'' Wawrinka said. "I'm enjoying it a lot.''
Also, Stefanos Tsitsipas saved two match points before getting past Grigor Dimitrov 6-3, 5-7, 7-6 (4); and Marcos Giron, an American qualifier, picked up his fourth win and five days by beating 2020 finalist Diego Schwartzman 6-1, 7-6 (4).
Wearing a ribbon with the colors of Ukraine's flag pinned to her hat, defending women's champion Iga Swiatek extended her winning streak to 24 matches with a 6-3, 6-0 victory over Romanian qualifier Elena-Gabriela Ruse.
The top-ranked player from Poland will next face former No. 1 Victoria Azarenka, who beat Camila Osorio 6-2, 6-4.