Alashkert FC ALA 0 - 0 |  Rangers RAN | FT | Vazgen Sargsyan Republican Stadium, Yerevan, Armenia | 6,800 |
| Rangers win 1-0 on aggregate |
HJK Helsinki HJKH 2 - 5 |  Fenerbahce FEN | FT | Bolt Arena, Helsinki, Finland | 3,785 |
| Fenerbahce win 6-2 on aggregate |
FC Zorya Luhansk FCZA 2 - 3 |  Rapid Vienna VIE | FT | Slavutych Arena, Zaporizhya, Ukraine | 2,563 |
| Rapid Vienna win 6-2 on aggregate |
Galatasaray GAL 2 - 1 |  Randers FC RAN | FT | Recep Tayyip Erdogan Stadyumu, Istanbul, Turkey | 3,947 |
| Galatasaray win 3-2 on aggregate |
AZ Alkmaar AZ 2 - 1 |  Celtic CEL | FT | AFAS Stadion, Alkmaar | 10,041 |
| Celtic win 3-2 on aggregate |
CFR Cluj-Napoca CLUJ 1 - 2 |  Red Star Belgrade RSB | FT | Stadionul Dr. Constantin Radulescu, Cluj, Romania | 4,200 |
| Red Star Belgrade win 6-1 on aggregate |
Slovan Bratislava SLOV 2 - 2 |  Olympiakos OLY | FT | Národny Futbalovy Stadión, Bratislava, Slovakia | 7,201 |
| Olympiakos win 5-2 on aggregate |
Antwerp ANT 2 - 0 |  Omonia Nicosia OMON | FT-Pens | Bosuilstadion, Antwerp, Belgium | 10,470 |
| drawn 4-4 on aggregate. Antwerp advance 3-2 on penalties |
Legia Warsaw LEGI 2 - 1 |  Slavia Prague SLP | FT | Polish Army Stadium, Warsaw, Poland | 20,641 |
| Legia Warsaw win 4-3 on aggregate |
SK Sturm Graz STG 2 - 0 |  NS Mura NSM | FT | Merkur Arena, Graz, Austria | 8,237 |
| SK Sturm Graz win 5-1 on aggregate |
