NASHVILLE, Tenn. -- LSU always has played stingy defense. Now the Tigers have a high-octane offense and no plans at all to slow down anytime soon.
"Score, be aggressive," LSU coach Ed Orgeron said. "That's our mentality. We're going to be aggressive. We're going to go get it. We're not slowing down for anything."
The Tigers' aggressive approach paid off Saturday as Joe Burrow tossed four of his school-record six touchdown passes to Ja'Marr Chase and threw for 398 yards, leading No. 4 LSU to a 66-38 romp over Vanderbilt.
"They told me when it happened," Burrow said of his TD record. "I was more focused on going to get another one."
LSU (4-0, 1-0 Southeastern Conference) beat Vanderbilt (0-3, 0-2) for the eighth consecutive time. This marked the first meeting between these SEC charter members since 2010.
The Tigers scored their most points this season and most ever in regulation against an SEC opponent. The 104 combined points tied South Carolina's 65-39 victory over Mississippi State in 1995 for the fourth-highest scoring total in an SEC game that didn't go into overtime.
They needed 2 minutes, 11 seconds, or less on each of their first seven scoring drives. LSU also scored 4 seconds after Micah Baskerville returned an onside kick 46 yards to open the third quarter on Burrow's fifth TD pass.
Baskerville later blocked a punt he recovered for a score.
Burrow had a game for the record books.
He became both the first LSU quarterback to throw for 350 yards or more in three consecutive games. His 357 yards passing by halftime also was the most in school history.
Burrow hit 13 of his first 14 passes for 244 yards before throwing his second incompletion at 9:19 in the second quarter. He finished 25-of-34 and left the game early in the fourth quarter.
"It's good," Orgeron said. "I think that there's more to come. I really do. I think Joe is a fantastic player. He has a fantastic coach in [offensive coordinator] Steve Ensminger. We have a great plan, and as long as we protect the quarterback we're going to make big plays here at LSU."
And Burrow kept throwing to Chase. The sophomore caught TDs of 64, 25 and 51 yards in the first quarter and adding a 16-yarder in the third. He finished with 10 receptions for 229 yards, most by an LSU receiver since Odell Beckham Jr. had 204 against Furman in 2013.
"I'm just happy I played today," Chase said after not seeing the field against Northwestern State last week in a coach's decision.
Vanderbilt had never before played two of the nation's top five teams within the first three weeks of a season. At least the Commodores scored on their first drive, which they didn't manage in an opening defeat to No. 3 Georgia or a loss at Purdue. They scored their most points yet this season but had two turnovers.
"We were playing with house money, man," Vanderbilt coach Derek Mason said. "We had a chance to really take some chances, try to force some things to happen. Those things didn't necessarily go our way. But what I can tell you is the early part of the season, man, has been a difficult stretch."
LSU led 28-7 after the first quarter, 38-17 at halftime and 59-31 after the third.
LSU: The Tigers entered the day second in the SEC defending the run, giving up just 80.3 yards a game. They gave up a 41-yarder to Ke'Shawn Vaughn on Vandy's first offensive play. Vaughn also broke loose for a 52-yard TD run in the third quarter -- the longest run this season for the SEC's top returning rusher. Vaughn finished with 20 carries for 130 yards.
Vanderbilt: The Commodores came in as the only FBS team without a sack this season, and the closest they came to hitting Burrow early was on a roughing-the-passer penalty in the first quarter. Then Jaylen Mahoney sacked the LSU quarterback early in the second quarter, a play after Burrow had plenty of time to roll to his right before finding Stephen Sullivan on a 30-yard completion. Kenny Hebert also got a sack, and Elijah McAllister recovered an Edwards-Helaire fumble for a touchdown in the final minute of the first half.
LSU receiver Terrace Marshall Jr., who came into the game with six touchdown catches to tie for the FBS lead, was on crutches after four receptions for 75 yards. Orgeron said it didn't look good. LSU middle linebacker Michael Divinity Jr. hurt an ankle and was seen in a walking boot. Orgeron said it "looked pretty significant."
LSU: Open date before hosting Utah State on Oct. 5.
Vanderbilt: Hosts Northern Illinois on Sept. 28.
Alabama QB Tua Tagovailoa set to have hip surgery on Monday
Alabama quarterback Tua Tagovailoa is scheduled to have hip surgery Monday after being evaluated in Houston, orthopedic surgeon Lyle Cain said in a statement released Sunday night.
College football bowl projections
There are still big games left on the schedule, but see how our experts envision the entire bowl season playing out.
AP college football poll reaction: What's next for each Top 25 team
The new AP Top 25 poll is out. Here's what's next for each ranked team
Georgia edges past Alabama to No. 4 in AP poll
Georgia edged past Alabama to No. 4 in The Associated Press college football poll after the Bulldogs had a quality road victory and the Crimson Tide lost star quarterback Tua Tagovailoa for the season.
SP+ rankings after Week 12: The battle of the 1-loss teams
The College Football Playoff arguments are just starting to heat up -- especially when you get past the three unbeatens -- and SP+ is here to help.
How will Tua's injury affect his draft stock?
Mel Kiper Jr. breaks down how Tua Tagovailoa's latest injury complicates matters when it comes to his NFL draft prospects.