Lazio forward Ciro Immobile struck twice and Marco Parolo scored his first Champions League goal aged 35 as they beat Zenit St Petersburg 3-1.
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Felipe Caicedo produced another of his familiar late strikes to give Lazio a 1-1 draw at Zenit St. Petersburg.
Lazio produced the most dramatic comeback of the Serie A season so far when they scored twice in stoppage time to win 4-3 at Torino on Sunday.
Joaquin Correa scored early for a depleted Lazio but his side were held to a 1-1 draw by Club Brugge in an entertaining Champions League clash.
Luis Alberto set Lazio to a 2-1 win over Bologna with a superb solo effort in Serie A on Saturday after the visitors had a goal disallowed.
Lazio's Ciro Immobile scored against his former club Borussia Dortmund in a 3-1 home victory marking their return to the Champions League.
Striker Fabio Quagliarella set Sampdoria on the way to a comfortable 3-0 win at home to a disappointing Lazio in Serie A on Saturday.
Inter Milan dropped their first two points of the season when they were held to a 1-1 draw by Lazio.