Manchester City defender Esme Morgan suffered a broken leg in the Women's Super League game against Tottenham Hotspur on Sunday.
Newcomers Leicester City lost 3-1 to Manchester United in their first FA Women's Super League home game.
Manchester City kicked off their Women's Super League campaign with a 4-0 win at Everton, while Tottenham enjoyed victory over Birmingham City.
Matildas forward Kyah Simon has joined English Women's Super League club Tottenham on a multi-year deal.
Chelsea will begin their Women's Super League title (WSL) defence with a trip to London rivals Arsenal.
Striker Sam Kerr scored a goal in each half as Chelsea beat Tottenham Hotspur 2-0 to move back to the top of the FA Women's Super League.
United States women's national team forward Christen Press was on target as Manchester United beat Tottenham 4-1.
Five members of the USWNT's 2019 World Cup-winning squad joined English clubs earlier this year. Is this a new trend? Well, it's complicated.
USWNT's Alex Morgan will return to Orlando Pride for 2021 after spending the first half of the 2020-21 season with Tottenham.
Manchester City grabbed a late winner at home to Arsenal to stay in the title race while USWNT striker Alex Morgan scored one goal and made another.
USWNT's Alex Morgan scored a penalty on Saturday for her first goal since giving birth to her daughter Charlie, as Tottenham beat Brighton 3-1.
Alex Morgan missed the crucial penalty for Tottenham as they suffered defeat in the shootout to Arsenal in Women's Super League Cup on Wednesday.
Alex Morgan's first appearance for the United States since last year's World Cup final could come later this month against the Netherlands.
Tottenham and USWNT forward Alex Morgan made her first competitive appearance for Spurs against Reading in the Women's Super League on Saturday.
USWNT's Alex Morgan has said that her Tottenham debut has been delayed, and she will be out of action for "another few weeks."
Arsenal and Tottenham face off in the north London derby on Sunday with Spurs seeking to make up for missed opportunities.
Tottenham and Australia defender Alanna Kennedy has said the Matildas are embracing the expectation being placed on them.
A Millie Turner header was the only difference between Manchester United and Tottenham Hotspur on Saturday.
Tottenham and United States forward Alex Morgan has said she is still not fit enough to play 90 minutes but is hopeful she will play soon.
Alex Morgan joined Tottenham on a one-year deal but hasn't played competitive football since giving birth to her daughter in May.
Orlando Pride coach Marc Skinner hopes Alex Morgan will return from her Tottenham stint for the start of the NWSL season.
Alex Morgan is the latest United States women's national team player to join the Women's Super League.