Real Betis handed Manchester United a second loss in as many outings in a 1-0 friendly win at the Benito Villamarín Stadium in Sevilla on Saturday.
Nabil Fekir turned home a cross from Borja Iglesias from a set piece to give the LaLiga side the game's only goal and the win.
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United, who are preparing to return to action following the conclusion of the World Cup in Qatar, started with a similar XI to the team that Erik ten Hag picked for Wednesday's 4-2 loss to Cadiz.
As with the previous friendly against Cadiz, United made wholesale changes at the break, giving their regular players not away on World Cup duty a 45-minute runout and offering chances to a host of reserve players.
Ten Hag's side sits in fifth place in the Premier League and will return to action on Dec. 21 with a Carabao Cup fourth round tie against Burnley before hosting Nottingham Forest in their first top-flight match since the World Cup break.