Two goals from Victor Osimhen helped Napoli climb to second in the Serie A standings after a comprehensive 4-1 win at Spezia on Saturday.
Ivan Perisic's equaliser earned Inter Milan a 1-1 draw at Spezia on Wednesday to move Antonio Conte's side one step closer to the Serie A title.
Spezia secured a huge win for their Serie A survival hopes by beating relegation rivals Cagliari 2-1 on Saturday.
Atalanta's Mario Pasalic bagged a double and Luis Muriel scored a superb goal as the hosts beat lowly Spezia 3-1 on Friday.
Cristiano Ronaldo marked his 600th league appearance with his 20th Serie A goal of the season as Juventus beat Spezia 3-0 on Tuesday.
Spezia felled another Serie A giant as they shocked league leaders AC Milan with a dominant display in a 2-0 victory on Saturday.
A stoppage-time winner from Lorenzo Pellegrini sealed a 4-3 Serie A win for AS Roma against Spezia on Saturday.
AS Roma manager Paulo Fonseca said he was unaware of a substitutions mix-up in Tuesday's Coppa Italia defeat by Spezia after making six changes.
Spezia came from behind to earn a shock smash-and-grab 2-1 win at Napoli in Serie A on Wednesday despite being reduced to 10 men.