The Tigers moved to the top spot in the rankings after their 26th win in a row.
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Sam Crosa killed a 37-yarder field goal as time expired to give No. 17 Cincinnati a 20-17 victory over South Florida on Saturday night and at least a share of the American Athletic Conference East division title.
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The Tigers and Buckeyes could be the nation's best two teams, but Clemson showed it also belongs in the mix.
Desmond Ridder threw for a pair of touchdowns and Michael Warren II ran for two more during a dominant opening half, and No. 17 Cincinnati remained the only unbeaten team in American Athletic play by routing Connecticut 48-3 on Saturday.
The nation's top teams were off in Week 10, but there was still some movement ahead of some monster showdowns next Saturday.
Sam Crosa kicked a 32-yard field goal as time expired to give No. 17 Cincinnati a 46-43 victory over East Carolina on Saturday night.
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The Tigers stay in the top spot after a week with yet another high-profile upset.
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Gerrid Doaks ran for a pair of touchdowns and turned a short pass into a 28-yard score Saturday, helping No. 21 Cincinnati hold on for a 24-13 victory over Tulsa after losing its top running back.