Our NFL Nation reporters have the latest injury updates for key players, including Saquon Barkley, T.Y. Hilton and more entering Week 7.
- 8/14L 19-16
- 8/22W 15-10
- 8/29W 34-10
- 9/12W 41-33
- 9/19W 17-11
- 9/26L 30-28
- 10/3L 28-21
- 10/10L 17-10
- 10/24h:mm a z, US/Eastern
- 10/31h:mm a z, US/Eastern
- 11/7h:mm a z, US/Eastern
- 11/15h:mm a z, US/Eastern
- 11/21h:mm a z, US/Eastern
- 11/28h:mm a z, US/Eastern
- 12/5h:mm a z, US/Eastern
- 12/12h:mm a z, US/Eastern
- 12/19h:mm a z, US/Eastern
- 12/23h:mm a z, US/Eastern
- 1/2h:mm a z, US/Eastern
- 1/9h:mm a z, US/Eastern
- Full Schedule
San Francisco QB Jimmy Garoppolo will return to the starting lineup on Sunday, but the 49ers will be without several key players against the Indianapolis Colts, including backup QB Trey Lance.
Nineteen months after Buckner was traded from the Bay Area to Indianapolis, he returns to play his former team Sunday night.
North Dakota State produced two top-3 NFL draft picks in Wentz and Lance, who will take the stage in primetime on Sunday.
Aaron Rodgers and the Packers are feeling good after five wins in a row, while confidence is dropping in Brian Flores and the Dolphins and DK Metcalf and the Seahawks.
Our NFC West reporters discuss the strength of the division, its quarterbacks, biggest issues and which team will come out on top.
When coach Kyle Shanahan and his staff perform their self-scout during the bye, they'll see a 2-3 team that isn't far off from playoff contention.
Lindsey Thiry ESPN
NFC West roundtable: Breaking down the quarterback situations for the Cardinals, Seahawks, 49ers and Rams.
Rookies Justin Fields and Zach Wilson got their first wins, and there are plenty of things to celebrate for the other first-year QBs.
49ers rookie QB Trey Lance suffered a left knee sprain in Sunday's 17-10 loss to the Cardinals, coach Kyle Shanahan announced Monday.
Cameron Heyward is playing better than ever in Pittsburgh, Cordarrelle Patterson is hitting new heights in Atlanta and Taylor Heinicke has stepped up in Washington.
San Francisco 49ers rookie quarterback Trey Lance gave his first NFL start a strikingly similar review to his performance in the second half of last week's loss to Seattle: "Some good, some bad again."
— Zach Allen will enjoy his postgame trip to Shake Shack after an exhausting, physical win over the San Francisco 49ers. He and the rest of the Arizona Cardinals' defense certainly deserve a burger or two.
Green Bay and Cincinnati traded field goal misses in a wild one, the Lions squandered a chance, and the Eagles overcame a two-score deficit. What to know for every Week 5 game.
Nick Wagoner ESPN Staff Writer
49ers inactives: QB Jimmy Garoppolo (calf), CB K'Waun Williams (calf), CB Ambry Thomas, G Aaron Banks, WR Jauan Jennings, DT Zach Kerr, CB Buster Skrine
The 49ers have placed tight end George Kittle on injured reserve with a calf injury that he had played through since Week 1.
Can Odell Beckham Jr. be more consistent? Should fantasy managers be worried about CeeDee Lamb? Our reporters fill you in before Sunday's games.
Garoppolo is dealing with a strained and bruised right calf, which leaves the door open for Lance, the No. 3 pick overall out of NDSU.
San Francisco 49ers rookie quarterback Trey Lance will make his first NFL start Sunday against the undefeated Cardinals in place of injured Jimmy Garoppolo, coach Kyle Shanahan said Friday.
Adam Schefter ESPN Senior Writer
TE George Kittle is listed as doubtful for Sunday
Adam Schefter ESPN Senior Writer
Jimmy Garoppolo officially out Sunday vs. Arizona. Trey Lance will make his first NFL start.
One week after the Los Angeles Rams humbled the reigning Super Bowl champions, the Arizona Cardinals walked into SoFi Stadium and humbled the Rams.
Rookies Justin Fields and Zach Wilson got their first wins and there are plenty of things to celebrate for the other first-year QB.