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What will give when Titans' Derrick Henry meets Steelers No. 2 run defense?

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What have Roethlisberger, Tannehill been able to prove thus far? (2:54)

Steelers reporter Brooke Pryor and Titans reporter Turron Davenport preview the quarterback matchup between Ben Roethlisberger and Ryan Tannehill. (2:54)

Steelers (5-0) at Titans (5-0)

1 p.m. ET | CBS

Matchup rating: 72.5 | Spread: PIT -1.5 (50.5)

What to watch for: Tennessee running back Derrick Henry's 588 yards on the ground leads all rushers. The Steelers' run defense is second in the NFL, allowing 66 yards per game despite rarely loading the box to stop the run. Tennessee's play-action passing game has produced big plays this season, so the difference will come down to how well quarterback Ryan Tannehill can keep the Titans' offense on schedule against a Pittsburgh defense blitzing 60% of the time when teams use play-action against it. -- Turron Davenport

Bold prediction: Steelers wide receiver JuJu Smith-Schuster will have two touchdowns. Smith-Schuster has been quiet the past two games with even distribution in the passing game. But with Chase Claypool breaking out and defenses taking notice, that could free up some room for Smith-Schuster to get free and score for the first time since Week 3. -- Brooke Pryor

Stat to know: The Titans' offense has used play-action at the second-highest rate in the NFL since the start of 2019, and an NFL-high 47% of its passing yards in that span have come on play-action. Since Tannehill became the Titans' starter in Week 7 last season, his 92.1 QBR and 12.2 yards per attempt on play-action lead all NFL QBs, and his 15 TDs is tied with Kirk Cousins for the most in the NFL. But Pittsburgh's defense has been exceptional defending play-action, allowing the lowest QBR (38.9) and completion rate (57%) since the start of last season.

Injuries: Steelers | Titans

What to know for fantasy: Henry, fresh off 212 rushing yards against the Texans, faces a Steelers defense that has yet to allow more than 80 rushing yards to any single player and is allowing the second-fewest fantasy points per game to RBs this season (16.5). See Week 7 rankings.

Betting nugget: In the Super Bowl era, when teams that are 4-0 or better square off, the underdog is 10-4 against the spread (ATS). Read more.

Pryor's pick: Steelers 27, Titans 24

Davenport's pick: Titans 28, Steelers 24

FPI prediction: PIT, 52.0% (by an average of 0.8 points)

Matchup must-reads: Steelers' Spillane gets chance to show he belongs against former team ... Steelers' Roethlisberger, Titans' Tannehill silence doubters by winning ... Titans' offense cruising behind Henry, but Steelers pose challenge ... Source: Titans face fine as NFL ends virus audit