1 p.m. ET | CBS
Matchup rating: 28.7 | Spread: BUF -12 (45)
What to watch for: The Jets hope to have their full complement of wide receivers on the field for the first time, as rookie Denzel Mims is poised to make his NFL debut. Quarterback Sam Darnold is poised to start barring any sort of setback on his shoulder. But if he starts, he will have plenty of speed on the outside with Mims and Breshad Perriman. -- Rich Cimini
Bold prediction: The Bills won't call this a "get right" game, but I will. Not only does quarterback Josh Allen eclipse 320 passing yards, but Buffalo's defense will hold the Jets under 250 yards of total offense. -- Marcel Louis-Jacques
Stat to know: The Jets' minus-110 point differential is the second worst in franchise history through six games of a season (minus-122 in 1976). The team's worst mark through seven games also came in '76, when New York was outscored by 142. Will Buffalo surpass 32 points in this one?
What to know for fantasy: Allen was QB3 in Week 1 when these teams first met but is coming off his worst performance of the season on Monday night (QB17). See Week 7 rankings.
Betting nugget: The Jets are 0-6 ATS this season. That's two short of the longest winless streak to start a season against the spread over the past 20 seasons. The 2003 Raiders failed to cover in each of their first eight games of the season. Read more.
Louis-Jacques' pick: Bills 28, Jets 10
Cimini's pick: Bills 24, Jets 9
FPI prediction: BUF, 74.6% (by an average of 9 points)
Matchup must-reads: Bills' Allen vs. winning teams: "Staying patient" is key ... Jets' Darnold practices with hopes QB can start ... Bills release former starting guard Spain ... Blast from past: '96 Jets (1-15) say current team "shouldn't be this bad" ... Projected 2021 NFL draft order: Jets are favorite for No. 1